Malaria is a major public health problem in India, the world’s second most populous country with > 1 billion people. All four species of malaria parasite are endemic, and multiple species of mosquito are vectors. Malaria is indeed a complex disease in the subcontinent.We have collaborated with malaria researchers at several institutions in India since 2005, first through an NIH Fogarty International Center D43 Research and Training grant, and subsequently through the Center for the Study of Complex Malaria in India (CSCMi), described below.
Operational since 2010, the CSCMi is a U.S. National Institutes of Health-funded International Center of Excellence in Malaria Research, and a partnership between researchers at New York University and scientists and clinicians in India, under the leadership of Professor Jane Carlton. The overall goal of the CSCMi is to develop the knowledge, tools, and evidence-based strategies needed to support Indian malaria intervention and control programs, and to build research capacity in India. Our studies have been based at several field sites including Rourkela (Odisha), Chennai (Tamil Nadu), Nadiad (Gujarat), West Khasi Hills and Jaintai Hills (Meghalaya), and Jabalpur (Madhya Pradesh).
Some of the research projects we have undertaken as part of the CSCMi include:
Describing the epidemiology of P. vivax and P. falciparum in India
van Eijk AM et al. What is the value of reactive case detection in malaria control? A case-study in India and a systematic review. Malar J. 2016 Feb 6;15(1):67.
Laishram DD et al. The complexities of malaria disease manifestations with a focus on asymptomatic malaria. Malar J 2012, 11:29.
Kar NP et al. A review of malaria transmission dynamics in forest ecosystems. Parasit Vectors. 2014 Jun 9;7(1):265.
Identifying key elements of vector transmission in India van Eijk AM et al. The use of mosquito repellents at three sites in India with declining malaria transmission: surveys in the community and clinic. Parasit Vectors. 2016 Jul 27;9(1):418.
Waite JL, Swain et al. Increasing the potential for malaria elimination by targeting zoophilic vectors. Sci Rep. 2017 Jan 16;7:40551.
Thomas S et al. Overhead tank is the potential breeding habitat of Anopheles stephensi in an urban transmission setting of Chennai, India. Malar J. 2016 May 11;15(1):274.
Describing the genomic epidemiology of P. vivax and P. falciparum in India and globally: Neafsey DE et al. The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum. Nat Genet. 2012 Sep;44(9):1046-50.
Hupalo DN et al. Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax. Nat Genet. 2016 Aug;48(8):953-8.
Developing methods and monitoring Plasmodium drug resistance in India: Mideo N at al. Ahead of the curve: next generation estimators of drug resistance in malaria infections. Trends Parasitol. 2013 Jul;29(7):321-8.
Mideo N et al. A deep sequencing tool for partitioning clearance rates following antimalarial treatment in polyclonal infections. Evol Med Public Health.
Rao PN et al. A Method for Amplicon Deep Sequencing of Drug Resistance Genes in Plasmodium falciparum Clinical Isolates from India. J Clin Microbiol. 2016 Jun;54(6):1500-11.
Characterizing the host immune response to malaria parasites in India: Uplekar S et al. Characterizing Antibody Responses to Plasmodium vivax and Plasmodium falciparum Antigens in India Using Genome-Scale Protein Microarrays. PLoS Negl Trop Dis. 2017 Jan 24;11(1):e0005323.
Studying the pathogenesis of cerebral malaria in India:
Mohanty S et al. Magnetic resonance imaging during life: the key to unlock cerebral malaria pathogenesis? Malar J. 2014 Jul 18;13(1):276.
Mohanty S et al. Magnetic Resonance Imaging of Cerebral Malaria Patients Reveals Distinct Pathogenetic Processes in Different Parts of the Brain. mSphere. 2017 Jun 7;2(3).
CSCMi Team - May 2016